Method for treating and/or preventing regnase-1-related disease
OwnerShizuo AKIRA, Takashi SATOH +3inventors
InventorsShizuo AKIRA, Takashi SATOH, Hiroki TANAKA, Keiko SAITO, Yusuke YAMAGISHI
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Abstract
The present invention found that, for example, inhibiting phosphorylation of a Ser residue in Regnase-1 is effective in treating and/or preventing diseases. The invention also found that, for example, inhibiting the binding of Regnase-1 with at least one factor selected from the group consisting of TBK1, IKKi, Act-1, IKK, and IRAK is effective in treating and/or preventing diseases.
Claims9
-17. (canceled)
A cyclic polypeptide that inhibits phosphorylation of a Ser residue at least one position selected from the group consisting of positions corresponding respectively to positions 513, 494, 439, and 435 of SEQ ID NO:
- 1 in Regnase-1, wherein the polypeptide competes for binding to Regnase-1 with at least one compound selected from PP1 to PP25 shown below, and the polypeptide comprises 8 to 15 amino acids and amino acid analogs in total.
Dependencies are inferred from the claim text.