Bacillus velezensis compositions and methods of use thereof

A composition comprising Bacillus velezensis strain BV379 or progeny thereof, wherein the strain or progeny thereof is heat-treated, filtered to remove viable cells, or both;

• or a composition comprising a lysate or supernatant preparation of Bacillus velezensis strain BV379 or progeny thereof, wherein a sample of the strain has been deposited under ATCC Accession No. PTA-127359.

A method of reducing gastrointestinal symptoms, supporting digestive health, decreasing pathogenic microbes in the gut microbiota, increasing beneficial microbes in the gut microbiota, or inhibiting the growth of pathogenic microbes in the gastrointestinal tract, in a human or an animal in need thereof, comprising administering an effective amount of a composition comprising Bacillus velezensis to said human or animal.