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AssigneeMedipost Co., Ltd.
InventorsYun Sun YANG, Won Il OH, Soo Jin CHOI, Hye Jin JIN, Yun Kyung BAE, Hyang Ju LEE
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Proposed is a composition for preventing or treating lung diseases. The composition may contain CD47-overexpressing mesenchymal stem cells as an active ingredient. CD47-overexpressing mesenchymal stem cells, even when not autologous, show a high survival rate in vivo and the ability to migrate to lung tissue, reduce the inflammatory response in lung tissue, and exhibit a fibrosis-inhibiting effect. CD47-overexpressing mesenchymal stem cells can be widely used for the prevention or treatment of various lung diseases related to inflammation or fibrosis of the lungs.
A method for preventing or treating lung disease, comprising administering, to a subject, a composition comprising mesenchymal stem cells expressing CD47 as an active ingredient.
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Use of mesenchymal stem cells expressing CD47 for the manufacture of a therapeutic agent for the prevention or treatment of lung disease.
Dependencies are inferred from the claim text.