Fecal transplants for reversing motor and gut symptoms in neurodevelopmental disorders
AssigneeCalifornia Institute of Technology
InventorsSarkis K. Mazmanian, Matheus de Castro Fonseca
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Abstract
Disclosed herein are methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
Claims31
A method of treating, improving and/or delaying a neurodegenerative disorder or a symptom thereof in a subject in need thereof, the method comprising:
- identifying a subject having a neurodegenerative disorder, or a symptom thereof;
- administering to the subject a composition comprising an effective amount of fecal microbiota,
- wherein the fecal microbiota is derived from a healthy subject;
- and
- wherein the neurodegenerative disorder or the symptom thereof of the subject is treated, improved and/or delayed after administering the composition.
A method of treating, improving and/or delaying a neurodegenerative disorder or a symptom thereof in a subject, the method comprising:
- identifying a subject having the neurodegenerative disorder or a symptom thereof;
- determining an age of the subject having the neurodegenerative disorder or a symptom thereof;
- and
- administering to the subject a composition comprising an effective amount of fecal microbiota,
- wherein the fecal microbiota is derived from a healthy subject, and
- wherein the healthy subject is at least 10 years younger than the subject having the neurodegenerative disorder or a symptom thereof.
Dependencies are inferred from the claim text.