Cannabinoid compositions for gastroesophageal disorders
AssigneesThe United States Government as represented by the Department of Veterans Affairs, The Brigham and Women's Hospital, Inc.
InventorsAaron J. Goldman, Gabriel Gonzalez, Natasha Y. Frank
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Abstract
Compositions comprising a cannabinoid and other compounds, such as terpenes, and methods of using such compositions. The disclosed compositions can be useful in, for example, treating and preventing esophageal adenocarcinoma and related diseases such as esophageal dysplasia, esophageal metaplasia, Barrett's Esophagus, gastroesophageal reflux disorder (GERD), or conditions associated with acid-biliary reflux.
Claims30
A pharmaceutical composition comprising:
- a) a cannabinoid represented by Formula (I):
- wherein R1 is hydrogen or methyl;
- R2 is hydrogen or —COOH;
- R3 is C3-C5 alkyl;
- or a salt thereof;
- and
- b) a compound represented by Formula (II):
- wherein R4 is halide or —OR5;
- wherein R5, when present, is hydrogen or —COR6;
- wherein R6, when present, is C1-C18 alkyl, or aryl;
- or
- c) a terpene selected from (E)-β-caryophyllene, (Z)-β-caryophyllene, caryophyllene oxide, α-humulene, myrcene, limonene, linalool, or pinene;
- wherein the cannabinoid and the compound represented by Formula (II), or the terpene, are present at a non-naturally occurring molar ratio;
- and
- wherein the compound represented by Formula (II), or the terpene, is present at a molar amount that exceeds the molar amount of the cannabinoid.
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A hydrogel comprising:
- a) a polymer formed from an alginate and a hydrophobic amine;
- b) a cannabinoid represented by Formula (I):
- wherein R1 is hydrogen or methyl;
- R2 is hydrogen or —COOH;
- R3 is C3-C5 alkyl;
- or a salt thereof;
- and
- c) a compound represented by Formula (II):
- wherein R4 is halide or —OR5;
- wherein R5, when present, is hydrogen or —COR6;
- wherein R6, when present, is C1-C18 alkyl, or aryl;
- or
- d) a terpene selected from (E)-β-caryophyllene, (Z)-β-caryophyllene, caryophyllene oxide, α-humulene, myrcene, limonene, linalool, or pinene;
- wherein the cannabinoid and the compound represented by Formula (II), or the terpene, are present at a non-naturally occurring molar ratio;
- and
- wherein the compound represented by Formula (II), or the terpene, is present at a molar amount that exceeds the molar amount of the cannabinoid.
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Dependencies are inferred from the claim text.