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US 2025/0017945 A1Published application
Liposomal formulations of corticosteroids and uses thereof
AssigneeEDEN Opthalmic PTE Ltd.
InventorsSubramanian VENKATRAMAN, Chee Wai WONG, Tina HOWDEN
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Abstract
The present disclosure provides ophthalmic compositions comprising a steroid, such as prednisolone encapsulated in a liposomal carrier and methods of use thereof.
Claims17
1-25. (canceled)
An ophthalmic composition suitable for ocular injection, comprising
- (i) prednisolone encapsulated in a liposome, wherein the liposome comprises a phospholipid wherein the phospholipid is selected from the group consisting of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC)) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC);
- wherein the liposome has a diameter of about 100 nm to about 200 nm;
- wherein the liposome is free of added cholesterol and free of PEGylated lipid;
- wherein the prednisolone is present at about 3% to about 6% (w/w) of the liposome, and
- (ii) an aqueous buffer suitable for administration to the eye.
2 more elements
Dependencies are inferred from the claim text.