Flavanoid containing compositions and methods of use thereof for the treatment of mitochondrial disorders

Abstract

This disclosure is directed to methods of treating or inhibiting mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of and effective amount of one or more of (+) Epicatechin (−) epicatechin, 11-hydroxyprogesterone, and 11-β-hydroxypregnenolone and other efficacious agents in a pharmaceutically acceptable carrier. Agents can be administered alone or in certain synergistic combinations. The compositions and methods described effectively reduce or alleviate primary respiratory chain dysfunction symptoms, and have efficacy for improving cellular resiliency, stress resistance, and symptoms associated with primary, secondary, or acute respiratory chain dysfunction.

Dependencies are inferred from the claim text.