Neutral ph compositions of docetaxel and human serum albumin

A pharmaceutical composition comprising a non-covalently bound complex comprising docetaxel and human serum albumin, wherein the molar ratio of docetaxel and the human serum albumin in the composition is from about 0.1:1 to about 5:1, wherein the composition is a clear aqueous solution, wherein the human serum albumin in the composition is from commercial pharmaceutical human serum albumin solution for infusion, wherein the docetaxel concentration in the solution is higher than aqueous solubility of docetaxel, and wherein pH of the composition is from about 5 to about 8, and wherein the composition is produced by a method comprising the steps of:

• (i) obtaining an organic solution of docetaxel in a polar water-miscible organic solvent;
• (ii) obtaining a first aqueous solution comprising human serum albumin;
• and
• (iii) mixing the organic solution of docetaxel and the first aqueous solution of human serum albumin to obtain a second aqueous solution comprising the composition comprising docetaxel and human serum albumin,
• wherein mixing is carried out at ambient temperature.