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US 2025/0017890 A1Published application
Carbamoyl phenylalaninol analogs and uses thereof
AssigneeAxsome Malta Ltd.
InventorFionn HURLEY
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Abstract
The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.
Claims20
A compound having Formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- W is CH2 or NH;
- R is optionally substituted C1-8 alkyl, halogen, optionally substituted C14 alkoxy, cyano, hydroxy, optionally substituted trifluoromethyl, or C1-4 thioalkoxy;
- n is 0, 1, 2, or 3, with the proviso that R may be the same or different when x is 2 or 3;
- and
- R1 and R2 can be the same or different and are independently selected from the group consisting of hydrogen, optionally substituted C1-8 alkyl, optionally substituted amide, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted C3-7 cycloalkyl;
- or R1 and R2 can be joined to form a 5 to 7-membered heterocycle optionally substituted with alkyl or aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atoms.
4 more elements
Dependencies are inferred from the claim text.