Treatment of inclusion body myositis with phenylbutyrate and monitoring of treatment
AssigneeUniversity of Kansas
InventorsDuaa Jabari, Richard J. Barohn, Mazen M. Dimachkie, Heather Wilkins
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Abstract
A method for treating inclusion body myositis (IBM) in a subject can include: providing a subject that has IBM; administering phenylbutyrate (PBA) to the subject in a therapeutically effective amount to provide a treatment for the IBM; obtaining at least one biological sample from the subject after initiation of the treatment for the IBM; measuring a biological indicator in the at least one biological sample, wherein the biological indicator is mitochondrial membrane potential; and monitoring a change in the biological indicator as an indication of effectiveness of the treatment.
Claims20
A method for treating inclusion body myositis (IBM) in a subject, comprising:
- providing a subject that has IBM;
- administering phenylbutyrate (PBA) to the subject in a therapeutically effective amount to provide a treatment for the IBM;
- obtaining at least one biological sample from the subject after initiation of the treatment for the IBM;
- measuring a biological indicator in the at least one biological sample, wherein the biological indicator is mitochondrial membrane potential;
- and
- monitoring a change in the biological indicator as an indication of effectiveness of the treatment.
Dependencies are inferred from the claim text.