Novel tetrahydrocurcumin compositions, methods of making, and methods of using the same
AssigneeRenibus Therapeutics, Inc.
InventorsDonald Jeffrey Keyser, Alvaro F. Guillem, Bhupinder Singh, Richard A. Zager
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Abstract
The present invention relates to novel tetrahydrocurcumin (THCu) compositions, novel methods of manufacturing, and methods of using these compositions for therapeutic applications. The novel synthetic pathway(s) result in THCu compositions that generally lack hexahydrocurcumin (HHC), and include an improved impurity profile with reduced additional species that are generally present in hydrogenated curcumin compositions.
Claims20
A parenteral composition comprising tetrahydrocurcumin (THCu) according to the formula:
- b) polyethylene glycol (PEG), and
- c) a pharmaceutically acceptable excipient, wherein the composition lacks detectable amounts of hexahydrocurcumin (HHC) as indicated by no peak with a relative retention time of 7.14-7.15.
The parenteral composition of claim 1, wherein the composition comprises between 0.1 to 1 wt % PEG.
A method of treating or preventing a disorder, wherein the method comprises administering a pharmaceutical composition comprising tetrahydrocurcumin (THCu) according to the formula:
- and
- b) a pharmaceutically acceptable excipient, wherein the pharmaceutical composition lacks detectable amounts of hexahydrocurcumin (HHC) as indicated by no peak with a relative retention time of 7.14-7.15.
Dependencies are inferred from the claim text.