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US 2025/0017865 A1Published application
Extracellular vesicles or composition thereof for use as a medicament, such as for the treatment of ocular surface disorders
OwnerEric GABISONinventor
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Abstract
The invention provides extracellular vesicles (EVs) or composition thereof for use as a medicament, in particular for use in the treatment or the prevention of an ocular surface blinding disorder (OSBD), wherein said EVs are produced by a genetically modified cell comprising one or more recombinant nucleic acid sequence(s) expressing recombinant Paired Box 6 (rPAX6) and/or recombinant type VII Collagen (rCOL7A1).
Claims11
(canceled)
Method of treating or preventing an ocular surface blinding disorder (OSBD) of a subject comprising administering to said subject extracellular vesicles (EVs) or a composition thereof,
- wherein said EVs are produced by a genetically modified cell comprising one or more recombinant nucleic acid sequence(s) expressing recombinant Paired Box 6 (rPAX6) and/or recombinant type VII Collagen (rCOL7A1);
- and
- wherein said EVs contain (i) rPAX6 proteins and/or rPAX6 mRNAs;
- and/or (ii) rCOL7A1 proteins and/or rCOL7A1 mRNAs.
1 more element
Dependencies are inferred from the claim text.