Solid dispersion, preparation method, and pharmaceutical composition thereof

A preparation method of a solid dispersion, comprising:

• mixing lurasidone or its pharmaceutically acceptable salt and a carrier to form a mixture, wherein the carrier comprises polyvinyl acetate phthalate, polyvinyl alcohol, cellulose acetate phthalate, mesoporous silica, hydroxypropyl methycellulose, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose, povidone, copovidone, ethyl cellulose, polyoxyethylene glycol, hypromellose acetate succinate, hypromellose phthalate, or a combination thereof;
• and
• spray drying the mixture, or
• melting and then cooling the mixture.

A solid dispersion, comprising:

• lurasidone or its pharmaceutically acceptable salt;
• a carrier;
• and
• a surfactant, wherein the surfactant comprises glycerol esters, polyoxyethylene esters, or a combination thereof.