Novel senotherapy peptide and composition containing the same
AssigneeAmorepacific Corporation
InventorsHyuk KIM, Sunyoung PARK, Si Young CHO, Sang Hyun MOH, Jeong Hun LEE, Hyo Hyun SEO, Hye In KIM
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Abstract
A novel senotherapy peptide and a method for senotherapy are disclosed. The method for sentherapy includes administering an effective amount thereof to a subject in need thereof. The novel senotherapy peptide suppresses the interaction between p53 and FOXO4 in the nucleus due to a better binding force with p53 than FOXO4, thereby allowing p53 to be released out of the nucleus and move to mitochondria to induce apoptosis of senescent cells and selectively induce the apoptosis of senescent cells in the skin cells.
Claims11
A peptide containing the amino acid sequence of SEQ ID NO:
- 1.
A method for improving skin wrinkles, comprising administering an effective amount of a peptide containing the amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof.
A method for senotherapy, comprising administering an effective amount of a peptide containing the amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof.
Dependencies are inferred from the claim text.