Sterile or sterilized package for administration of medicinal or nutritional substances

A package for administration of medicinal or nutritional substances, comprising:

• an outer bag with a sterilized inner chamber,
• a bottle of medicinal or nutritional substance set in an overturned position and disposed within the inner chamber of the outer bag, the bottle comprising a neck and a pierceable cap set in the neck,
• a device configured to withdraw or reconstitute the medicinal or nutritional substance contained in the bottle, wherein the device comprises:
• an upper body having flaps hooked to the neck of the bottle, and
• a lower body slidably coupled to the upper body, the lower body comprises:
• a perforation needle configured to move in an axial direction relative to the bottle and perforate the cap of the bottle, and
• a bottom shank extending from a base of the needle, and
• an outflow tube hermetically receiving the bottom shank and extending out of the outer bag, the outflow tube comprising an openable closure element disposed in a passage of the outflow tube,
• wherein said perforation needle comprises:
• a first channel establishing fluid communication between an interior of the bottle and the passage of the outflow tube when the perforation needle perforates the cap and the closure element is opened,
• a second channel establishing fluid communication between the inner chamber of the outer bag and the interior of the bottle, and
• a hydrophobic filter disposed in the second channel and within the base of the perforation needle to allow only gaseous fluid to flow through the second channel,
• wherein the base of the perforation needle extends below the upper body when the perforation needle is moved upward in the axial direction relative to the bottle and perforates the cap of the bottle.