Mechanical thrombectomy assembly with embolic protection, and associated devices, systems, and methods

#The present technology generally relates to mechanical thrombectomy assemblies, including mechanical thrombectomy assemblies with embolic protection, and associated devices, systems, and methods.

#Thromboembolic events are characterized by an occlusion of a blood vessel. Thromboembolic disorders, such as stroke, pulmonary embolism, heart attack, peripheral thrombosis, atherosclerosis, and the like, affect many people. These disorders are a major cause of morbidity and mortality.

#When an artery is occluded by a clot, tissue ischemia develops. The ischemia will progress to tissue infarction if the occlusion persists. However, infarction does not develop or is greatly limited if the flow of blood is reestablished rapidly. Failure to reestablish blood flow can accordingly lead to the loss of limb, angina pectoris, myocardial infarction, stroke, or even death.

#Many aspects of the present technology can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale. Instead, emphasis is placed on illustrating clearly the principles of the present disclosure.

#FIG. 1A is a partially schematic side view of a clot treatment system configured in accordance with embodiments of the present technology.

#FIG. 1B is a side view of a clot treatment system configured in accordance with additional embodiments of the present technology.

#The present technology is generally directed to clot treatment systems with integrated/systemized mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, an integrated clot treatment system includes an embolic protection device, a clot treatment device, a first shaft, and a second shaft. The embolic protection device can be carried by the first shaft and the clot treatment device can be carried by the second shaft. In some embodiments, the second shaft is slidably positioned within the first shaft. During a clot removal procedure, the clot treatment device and the embolic protection device can be inserted together while radially constrained within a delivery catheter into a blood vessel of patient including clot material to be treated. The delivery catheter can be retracted proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then the delivery catheter can be further retracted proximally to deploy the embolic protection device at least partially proximal to the clot material. The clot treatment device can be used to mechanically engage and disrupt the clot material by, for example, retracting the clot treatment device proximally through the clot material and into the embolic protection device and/or the first shaft. The embolic protection device can be positioned to capture all or a portion of the clot material that embolizes or otherwise breaks off during mechanical engagement of the clot treatment device with the clot material and/or to direct clot material into the first shaft.

#In some aspects of the present technology, the embolic protection device is integrated with the clot treatment device within the clot treatment system such that the clot treatment system can be easier to operate compared to other devices with separate embolic protection devices. In additional aspects of the present technology, the embolic protection device can be used to directly deploy the clot treatment device, which is expected to allow the clot treatment systems of the present technology to have a reduced profile (e.g., a smaller outer diameter) and/or to be easier to navigate through relatively smaller blood vessels, stenotic blockages, and/or thrombotic occlusions.

#Certain details are set forth in the following description and in FIGS. 1A-13G to provide a thorough understanding of various embodiments of the present technology. In other instances, well-known structures, materials, operations, and/or systems often associated with intravascular procedures, clot removal procedures, clot treatment systems, clot treatment devices, embolic protection devices, catheters, and/or the like are not shown or described in detail in the following disclosure to avoid unnecessarily obscuring the description of the various embodiments of the technology. Those of ordinary skill in the art will recognize, however, that the present technology can be practiced without one or more of the details set forth herein, and/or with other structures, methods, components, and so forth. Moreover, although many of the devices and systems are described herein in the context of removing and/or treating clot material, the present technology can be used to remove and/or treat other unwanted material in addition or alternatively to clot material, such as thrombi, emboli, plaque, intimal hyperplasia, post-thrombotic scar tissue, etc. Accordingly, the terms “clot” and “clot material” as used herein can refer to any of the foregoing materials and/or the like.