Sequencing and strategies for enhancing intravascular thrombus disruption with phase-change cavitation enhancing agents

A system for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent, the system comprising:

• at least one cavitation enhancing agent capable of being administered into a blood vessel of a subject;
• a receiver for monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot;
• and
• a timing controller for controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel, wherein the first time period is based on results of the monitoring to determine when the at least a portion of the at least one cavitation enhancing agent reaches the blood clot and the second time period is based on a time for the at least one cavitation enhancing agent to initiate disruption of the blood clot.