The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.
Drawings
Claims21
1-30. (canceled)
A computer-implemented method for facilitating risk assessment of coronary artery disease (CAD) of a subject based on image processing analysis of a medical image of the subject and compound analysis of stenosis, atherosclerosis, and ischemia derived from the image processing analysis, the method comprising:
accessing, by a computer system, a medical image of one or more coronary arteries of a subject;
analyzing, by the computer system using at least in part an image processing algorithm for image processing, the medical image of the one or more coronary arteries of the subject to identify one or more coronary arteries and one or more regions of plaque in the one or more coronary arteries, wherein the image processing algorithm is configured to identify one or more coronary arteries or one or more regions of plaque;
determining, by the computer system, one or more vascular morphology parameters of the identified one or more coronary arteries, the one or more vascular morphology parameters comprising one or more of lumen diameter or vessel wall diameter;
generating, by the computer system, analysis of presence or degree of stenosis based at least in part on the one or more vascular morphology parameters;
determining, by the computer system, one or more plaque parameters of the identified one or more regions of plaque, the one or more plaque parameters comprising volume or characterization of the identified one or more regions of plaque, the characterization of the one or more regions of plaque comprising one or more of low density non-calcified plaque, non-calcified plaque, or calcified plaque, wherein the characterization of the one or more regions of plaque is derived based at least in part on density values corresponding to the one or more regions of plaque;
generating, by the computer system, analysis of presence or degree of atherosclerosis based at least in part on the one or more plaque parameters;
generating, by the computer system, analysis of likelihood of presence or degree of ischemia based at least in part on the one or more vascular morphology parameters and the one or more plaque parameters;
and
generating, by the computer system, a preliminary compound assessment of risk of CAD of the subject, wherein the preliminary compound assessment of risk of CAD is based at least in part on a combination of the analysis of presence or degree of stenosis, the analysis of presence or degree of atherosclerosis, and the analysis of likelihood of presence or degree of ischemia,
wherein the computer system comprises a computer processor and an electronic storage medium.
7 more elements
A system for facilitating risk assessment of coronary artery disease (CAD) of a subject based on image processing analysis of a medical image of the subject and compound analysis of stenosis, atherosclerosis, and ischemia derived from the image processing analysis, the system comprising:
one or more computer readable storage devices configured to store a plurality of computer executable instructions;
and
one or more hardware computer processors in communication with the one or more computer readable storage devices and configured to execute the plurality of computer executable instructions in order to cause the system to:
access a medical image of one or more coronary arteries of a subject;
analyze, using at least in part an image processing algorithm for image processing, the medical image of the one or more coronary arteries of the subject to identify one or more coronary arteries and one or more regions of plaque in the one or more coronary arteries, wherein the image processing algorithm is configured to identify one or more coronary arteries or one or more regions of plaque;
determine one or more vascular morphology parameters of the identified one or more coronary arteries, the one or more vascular morphology parameters comprising one or more of lumen diameter or vessel wall diameter;
generate analysis of presence or degree of stenosis based at least in part on the one or more vascular morphology parameters;
determine one or more plaque parameters of the identified one or more regions of plaque, the one or more plaque parameters comprising volume or characterization of the identified one or more regions of plaque, the characterization of the one or more regions of plaque comprising one or more of low density non-calcified plaque, non-calcified plaque, or calcified plaque, wherein the characterization of the one or more regions of plaque is derived based at least in part on density values corresponding to the one or more regions of plaque;
generate analysis of presence or degree of atherosclerosis based at least in part on the one or more plaque parameters;
generate analysis of likelihood of presence or degree of ischemia based at least in part on the one or more vascular morphology parameters and the one or more plaque parameters;
and
generate a preliminary compound assessment of risk of CAD of the subject, wherein the preliminary compound assessment of risk of CAD is based at least in part on a combination of the analysis of presence or degree of stenosis, the analysis of presence or degree of atherosclerosis, and the analysis of likelihood of presence or degree of ischemia.
Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow: evaluating blood…
Life of this patent
Term end not estimated
Priority claimedParent application 62/958,032
Application filedUS 18/774,735
Assigned to Cleerly, Inc.assignment of assignor's interest
Published
Description74,154 words
Summary3,216 words
#The present application relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking.
#Coronary heart disease affects over 17.6 million Americans. The current trend in treating cardiovascular health issues is generally two-fold. First, physicians generally review a patient's cardiovascular health from a macro level, for example, by analyzing the biochemistry or blood content or biomarkers of a patient to determine whether there are high levels of cholesterol elements in the bloodstream of a patient. In response to high levels of cholesterol, some physicians will prescribe one or more drugs, such as statins, as part of a treatment plan in order to decrease what is perceived as high levels of cholesterol elements in the bloodstream of the patient.
#The second general trend for currently treating cardiovascular health issues involves physicians evaluating a patient's cardiovascular health through the use of angiography to identify large blockages in various arteries of a patient. In response to finding large blockages in various arteries, physicians in some cases will perform an angioplasty procedure wherein a balloon catheter is guided to the point of narrowing in the vessel. After properly positioned, the balloon is inflated to compress or flatten the plaque or fatty matter into the artery wall and/or to stretch the artery open to increase the flow of blood through the vessel and/or to the heart. In some cases, the balloon is used to position and expand a stent within the vessel to compress the plaque and/or maintain the opening of the vessel to allow more blood to flow. About 500,000 heart stent procedures are performed each year in the United States.
Brief description of the drawings90 figures
#The disclosed aspects will hereinafter be described in conjunction with the accompanying drawings, which are incorporated in and constitute a part of this specification, and are provided to illustrate and provide a further understanding of example embodiments, and not to limit the disclosed aspects. In the drawings, like designations denote like elements unless otherwise stated.
#FIG. 1 is a flowchart illustrating an overview of an example embodiment(s) of a method for medical image analysis, visualization, risk assessment, disease tracking, treatment generation, and/or patient report generation.
#FIG. 2A is a flowchart illustrating an overview of an example embodiment(s) of a method for analysis and classification of plaque from a medical image.
Detailed description68,207 words
#Although several embodiments, examples, and illustrations are disclosed below, it will be understood by those of ordinary skill in the art that the inventions described herein extend beyond the specifically disclosed embodiments, examples, and illustrations and includes other uses of the inventions and obvious modifications and equivalents thereof. Embodiments of the inventions are described with reference to the accompanying figures, wherein like numerals refer to like elements throughout. The terminology used in the description presented herein is not intended to be interpreted in any limited or restrictive manner simply because it is being used in conjunction with a detailed description of certain specific embodiments of the inventions. In addition, embodiments of the inventions can comprise several novel features and no single feature is solely responsible for its desirable attributes or is essential to practicing the inventions herein described.
#Disclosed herein are systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. Coronary heart disease affects over 17.6 million Americans. The current trend in treating cardiovascular health issues is generally two-fold. First, physicians generally review a patient's cardiovascular health from a macro level, for example, by analyzing the biochemistry or blood content or biomarkers of a patient to determine whether there are high levels of cholesterol elements in the bloodstream of a patient. In response to high levels of cholesterol, some physicians will prescribe one or more drugs, such as statins, as part of a treatment plan in order to decrease what is perceived as high levels of cholesterol elements in the bloodstream of the patient.
#The second general trend for currently treating cardiovascular health issues involves physicians evaluating a patient's cardiovascular health through the use of angiography to identify large blockages in various arteries of a patient. In response to finding large blockages in various arteries, physicians in some cases will perform an angioplasty procedure wherein a balloon catheter is guided to the point of narrowing in the vessel. After properly positioned, the balloon is inflated to compress or flatten the plaque or fatty matter into the artery wall and/or to stretch the artery open to increase the flow of blood through the vessel and/or to the heart. In some cases, the balloon is used to position and expand a stent within the vessel to compress the plaque and/or maintain the opening of the vessel to allow more blood to flow. About 500,000 heart stent procedures are performed each year in the United States.