Non-Invasive Topographic Localization Of Glymphatic Flow
AssigneeApplied Cognition, Inc.
InventorsPaul Dagum, Laurent B. Giovangrandi
Life of this patent
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Abstract
A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A device mounted on a subject's head during sleep can gather neurovascular data by measuring transcranial impedance. The device can be in the form of a single band, multiple bands, or a headcap that are worn on the subject's head. Electrodes located along an inner surface of the wearable device contact the subject's head and measure transcranial impedance. Transcranial impedance measurements are gathered from multiple locations on the subject's head and over multiple frequencies to obtain a more complete assessment of glymphatic flow.
Claims13
A device for topographic localization of glymphatic flow, the device comprising:
- a wearable device configured to be worn on the head of a subject, the wearable device comprising left electrodes and right electrodes, wherein the left electrodes and the right electrodes responsive electrical potential data;
- and
- a controller coupled to the wearable device, the controller comprising a-microcontroller and a power source that are electrically coupled to the left electrodes and the right electrodes;
- wherein at least one electrode of the left electrodes and the right electrodes is an input electrode that provides input currents over a range of frequencies that are generated by the power source and wherein other electrodes of the left electrodes and the right electrodes measure the responsive electrical potential data in response to the input currents, and
- wherein the device is configured to provide an indication of a change in the glymphatic flow that is localized to the left electrodes and the right electrodes by deriving left impedance data and right impedance data from the responsive electrical potential data over time.
Dependencies are inferred from the claim text.