Aqueous Hop Extracts and Their Use as Antimicrobial Agents
AssigneeNature Recombined Sciences Inc.
InventorsLeonard Sarna, Kian-Guan Lim, Mingyang Sun, Silvia Cardona, John Sorensen, Anna Motnenko
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Abstract
Described herein is the preparation of an aqueous hop extract and a boiling water hop extract prepared from dried hop cones that were ground prior to extraction. As discussed below, extracts were prepared from a number of different hop varieties and were tested against a number of clinically relevant bacterial strains. As discussed herein, surprisingly, the boiling water extract showed greater antibacterial activity than the aqueous extract.
Claims13
A method of treating a microbially contaminated surface comprising:
- applying a disinfectant composition to the microbially contaminated surface, the active ingredient of the disinfectant composition prepared by a method comprising:
- grinding a quantity of hop cones from hop plants,
- suspending the ground hop cones in a solution consisting of water, thereby providing forming an aqueous suspension;
- boiling the aqueous suspension for at least about 15, 20 or 30 minutes, and
- recovering the supernatant, thereby providing a boiling water hop extract;
- said disinfectant composition arresting microbial growth on the microbially contaminated surface.
A method of treating a Gram-positive bacterial infection in a patient in need of such treatment comprising administering an effective amount of a boiling water hop extract prepared by:
- grinding a quantity of hop cones from hop plants,
- suspending the ground hop cones in a solution consisting of water, thereby providing forming an aqueous suspension;
- boiling the aqueous suspension for at least about 15, 20 or 30 minutes,
- recovering the supernatant, thereby providing the boiling water hop extract,
- to a person who is suspected of having or who has been diagnosed with a Gram-positive bacterial infection.
A medicament comprising an effective amount of a boiling water hop extract prepared by:
- grinding a quantity of hop cones from hop plants,
- suspending the ground hop cones in a solution consisting of water, thereby providing forming_an aqueous suspension;
- boiling the aqueous suspension for at least about 15, 20 or 30 minutes,
- recovering the supernatant, thereby providing a boiling water hop extract,
- and a pharmaceutically acceptable diluent, carrier or excipient.
Dependencies are inferred from the claim text.