Tissue-engineered porous ceramic template and uses thereof
AssigneeOsteogene Bio Inc.
InventorDaniel S. Oh
Life of this patent
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Abstract
A tissue engineered three-dimensional model and related processes and apparatus. The model includes a three-dimensional porous ceramic template including a plurality of primary macro-pores; and cells cultured in the three-dimensional porous ceramic template, wherein at least some of the cells form one or more three-dimensional cellular matrices in the primary macro-pores. A process for preparing a tissue engineered three-dimensional model includes the steps of preparing the three-dimensional porous ceramic template, including a plurality of primary macro-pores; and culturing cells in the three-dimensional porous ceramic template, wherein at least some of the cells form one or more three-dimensional cellular matrices in the primary macro-pores.
Claims20
A tissue engineered three-dimensional model, comprising:
- a three-dimensional porous ceramic template including a plurality of primary macro-pores;
- and
- cells cultured in the three-dimensional porous ceramic template, wherein at least some of the cells form one or more three-dimensional cellular matrices in the primary macro-pores.
A process for preparing a tissue engineered three-dimensional model, comprising the steps of:
- preparing a three-dimensional porous ceramic template including a plurality of primary macro-pores;
- and
- culturing cells in the three-dimensional porous ceramic template, wherein at least some of the cells form one or more three-dimensional cellular matrices in the primary macro-pores.
An apparatus, comprising:
- a tissue engineered three-dimensional model, including:
- a three-dimensional porous ceramic template including a plurality of primary macro-pores;
- and
- cells cultured in the three-dimensional porous ceramic template, wherein at least some of the cells form one or more three-dimensional cellular matrices in the primary macro-pores;
- and
- a bioreactor system including:
- a culture column configured to receive the three-dimensional porous ceramic template;
- a culture medium vessel operably connected to the culture column;
- a peristaltic perfusion pump operably connected to the culture column and to the culture medium vessel, wherein the peristaltic perfusion pump is configured to apply a dynamic culture system within the culture column.
Dependencies are inferred from the claim text.