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AssigneeAmyris, Inc.
InventorsWilliam E. Draper, John E. Hung, Alex McGill, Victor Holmes
Estimating the term…
The present disclosure features compositions and methods for producing one or more cannabinoids, such as cannabidiolic acid (CBDa) or cannabidiol (CBD), in a host cell, such as a yeast cell, that is genetically modified to express the enzymes of a cannabinoid biosynthetic pathway. Using the compositions and methods of the present invention, the host cell may be genetically modified to express one or more enzymes of a cannabinoid biosynthetic pathway, such as CBDaS. The host cell may be cultured in the medium in the presence of a first cannabinoid, for example CBGa, and incubated for a time sufficient to allow for bioconversion of the first cannabinoid to a second cannabinoid, for example CBDa, by the host cell.
A genetically modified host cell capable of producing CBGa or CBG, wherein the genetically modified host cell comprises one or more heterologous nucleic acids that each, independently, encodes:
A genetically modified host cell capable of producing CBDa or CBD, wherein the genetically modified host cell comprises one or more heterologous nucleic acids that each, independently, encodes an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NOS:
A method for producing CBDa or CBD, comprising:
A method for producing CBDa or CBD comprising:
(canceled)
A fermentation composition comprising:
(canceled)
(canceled)
Dependencies are inferred from the claim text.