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US 2025/0002452 A1Published application
Bicyclopentane derivatives
AssigneesIcagen, Inc., Hoffmann-La Roche Inc.
InventorsMark CHAPMAN, Aaron GERLACH, Christopher John GRAHAM, Sylvain LEBRETON, David MOWREY, Anil NAIR, Roger David NORCROSS, Roger Lluis REDONDO PENA, Alena SAFAROVA, Martin SMRCINA, Luke James THOMPSON
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Abstract
The invention provides new bicyclopentanyl compounds having the general formula (I), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Claims43
A compound of formula (I), or a solvate, or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is selected from halogen, cyano, haloC1-6alkoxy, C1-6alkoxy, C1-6alkyl, C2-8alkynyl, cyanoC1-6alkoxy, haloC1-6alkyl, SF5, haloC2-6alkenyl, haloC1-6alkyl-thiol, and 4-6 membered heterocycloalkyl, which heterocycloalkyl is optionally substituted with one or two substituents independently selected from halogen and haloC1-6alkyl;
- R2 is selected from H, D, C1-6alkyl, hydroxyC1-6alkyl, and C1-6alkoxy;
- R3 is selected from H, D, C1-6alkyl, hydroxyC1-6alkyl, and C1-6alkoxy;
- or
- R2 and R3 together with the one carbon atom to which they are attached to, form a saturated monocyclic 3-6 membered cycloalkyl, which cycloalkyl is optionally substituted with one, two, three or four substituents independently selected from halogen and haloC1-6alkyl;
- R4 is selected from H, halogen, haloC1-6alkyl, C1-6alkoxy, and C1-6alkyl;
- R5 is selected from H, C1-6alkyl, hydroxyC1-6alkyl, and C1-6alkoxy;
- or R1 and R5, together with the two C-atoms they are attached to, form a 4-6 membered heterocycloalkyl ring system, which heterocycloalkyl is optionally substituted with one or two substituents independently selected from halogen and haloC1-6alkyl;
- and
- R8 is selected from H, halogen, haloC1-6alkyl, and haloC1-6alkoxy.
8 more elements
(canceled)
Dependencies are inferred from the claim text.