Therapy for programmed cell death in a subject transplanted with a donor liver carrying the pnpla3 rs738409:g variant

A method of promoting survival of a donor liver in a recipient subject, wherein the donor liver is homozygous for rs738409:G mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene, the method comprising administering to the subject a therapeutically effective amount of:

• (a) a nucleic acid molecule encoding glutathione peroxidase 4 (GPX4);
• or
• (b) glutathione (GSH);
• thereby promoting survival of the donor liver in the recipient subject.