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US 2025/0000672 A1Published application
Methods for repairing cartilage defects
AssigneeVericel Corporation
InventorsGraham Smith, Felix Ernesto Robles Toth, Richard P. Rodgers, Robert Bruce Mackinnon, III
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Abstract
The present disclosure describes methods for repairing cartilage defects by arthroscopic surgery to deliver cultured chondrocyte implants to defect sites. The implants may include bioresorbable matrices seeded with chondrocytes that are shaped to match cartilage defect sites, and which may be delivered to the cartilage defect sites by methods described in the present embodiments.
Claims21
An arthroscopic surgical method comprising:
- making at least two incisions in a subject adjacent to a defect to be treated arthroscopically, the at least two incisions comprising a first incision and a second incision;
- inserting a first cannula into the first incision;
- preparing a site of the defect to be treated at a joint in the subject;
- shaping a template material to match a shape of the prepared defect site to form a shaped template material;
- shaping a cell-seeded matrix to match a shape of the shaped template material by placing the cell-seeded matrix on top of the template material with the cells facing up and cutting the cell-seeded matrix to match the shape of the shaped template material;
- delivering the cell-seeded matrix to the prepared defect site through the first cannula;
- and
- fixating the delivered cell-seeded matrix using a glue.
5 more elements
A surgical kit comprising:
- two or more cannulas;
- a cell-seeded matrix comprising a bioresorbable support matrix and a plurality of cells seeded on a surface of the bioresorbable support matrix at a concentration of at least 250,000 cells/cm2;
- a surgical grasper;
- a templating material;
- one or more tools for shaping the template material and the cell-seeded matrix;
- one or more tools for outlining, cutting, and debriding cartilage.
3 more elements
A custom surgical device comprising:
- a handle;
- an adjustable knob rotatably coupled to a proximal end of the handle;
- a shaft coupled to the distal end of the handle;
- a movable joint coupled to the distal end of the shaft;
- and
- an adjustable distal end coupled to the moveable joint,
- wherein rotating the adjustable knob causes the adjustable distal end to rotate about the moveable joint such that an angle between the adjustable distal end and the shaft changes.
4 more elements
-24. (canceled)
Dependencies are inferred from the claim text.