Targeted retroviral integration for treatment of genetic disorders
AssigneeOhio State Innovation Foundation
InventorKristine YODER
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Abstract
Disclosed herein are methods and compositions related to modified prototype foamy virus (PFV) and its uses to treat diseases and disorders. Also disclosed are methods of making said PFVs.
Claims37
An engineered retroviral integration complex comprising an engineered prototype foamy virus (PFV) integrase (IN), two or more non-naturally occurring flanking nucleic acid sequences, and a cargo nucleic acid sequence.
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A method of expressing an exogenous nucleic acid in a subject in need thereof, comprising administering to the subject an engineered retroviral integration complex comprising an engineered prototype foamy virus (PFV) integrase (IN), two or more non-naturally occurring flanking nucleic acid sequences, and a cargo nucleic acid sequence, wherein the cargo nucleic acid is expressed in the subject.
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Dependencies are inferred from the claim text.