Compositions and methods of use thereof for treating liver fibrosis

Abstract

Compositions, methods of making compositions, and methods of using compositions for treatment of liver diseases, disorders, and damage are provided. The compositions can include chemically induced liver progenitor cells (CLiPs), and/or cell-free materials formed from the CLiPs such as extracellular vesicles (EVs) such as exosomes. In some embodiments, the compositions and/or methods are effective to reduce existing hepatic collagen or the formation of new hepatic collagen; and/or reduce the amount of existing fibrosis or the formation of new fibrosis in a subject in need thereof.

Dependencies are inferred from the claim text.