Bilirubin-coated radio-luminescent particles
AssigneePurdue Research Foundation
InventorsYou-Yeon Won, Vincenzo John Pizzuti, Dhushyanth Viswanath
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Abstract
The present disclosure relates to novel compositions comprising hydrophilic polymer-conjugated bilirubin-coated radio-luminescent particle or particle aggregates, and methods to make and use the novel compositions. A specific novel PEG-BR/CWO NP system provided in this disclosure comprises a CaWO4 nanoparticle (CWO NP) core encapsulated by a poly (ethylene glycol)-bilirubin conjugate micelle (PEG-BR micelle).
Claims17
A method of treating a disease responsive to a composition comprising:
- a radio-luminescent particle or particle aggregate;
- and
- a hydrophilic polymer-conjugated bilirubin;
- wherein the radio-luminescent particle or particle aggregate is encapsulated in the hydrophilic polymer-conjugated bilirubin
- wherein the method comprises administering the composition directly into the diseased site and exposing the diseased site to an ionizing radiation, wherein the ionizing radiation comprises UV light, X-rays, γ rays, electrons, protons, neutrons, ions, or any combination thereof.
A method of treating a patient with locally advanced primary or metastatic tumors, wherein the method comprises administering to the pateint a therapeutically effective amount of composition into the primary or metastatic tumors and exposing the tumors to an ionizing radiation, wherein the composition comprises:
- a radio-luminescent particle or particle aggregate;
- and
- a hydrophilic polymer-conjugated bilirubin;
- wherein the radio-luminescent particle or particle aggregate is encapsulated with the hydrophilic polymer-conjugated bilirubin.
Dependencies are inferred from the claim text.