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US 2024/0425547 A1Published application
PSMA Imaging Agents
AssigneeSiemens Medical Solutions USA, Inc.
InventorsEric Wang, Hartmuth C. Kolb, Anna Katrin Szardenings, Changhui Liu, Joseph C. Walsh, Gang Chen, Anjana Sinha, Dhanalakshmi Kasi, Chul Yu, Umesh B. Gangadharmath, Wei Zhang, Tieming Zhao, Vani P. Mocharla
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Abstract
Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
Claims16
A method comprising:
- administering to a patient, a radio-labelled compound of Formula VII:
- and pharmaceutically acceptable salts and stereoisomers thereof,
- wherein:
- X1 is CH or N;
- X2 is CH or N;
- X22 is a protecting group;
- and
- X23 is (CH2)1-10—NH2 wherein at least one CH2 of (CH2)1-10 is optionally replaced by at least one selected from the group consisting of S, O, NH, heteroaryl, cycloalkyl and heterocycloalkyl;
- scanning the patient using positron emission tomography or single photon emission computed tomography;
- and
- imaging a tissue in the patient.
8 more elements
A method of forming a compound comprising:
- reacting a compound of Formula VII with
- to form a first intermediate product;
- coupling the first intermediate product with another compound of Formula VII to form a second intermediate product;
- wherein the compound of Formula VII has the structure:
- and pharmaceutically acceptable salts and stereoisomers thereof, wherein:
- X1 is CH or N;
- X2 is CH or N;
- X22 is a protecting group;
- and
- X23 is (CH2)1-10—NH2 wherein at least one CH2 of (CH2)1-10 is optionally replaced by at least one selected from the group consisting of S, O, NH, CONH, aryl, heteroaryl, cycloalkyl and heterocycloalkyl;
- and
- removing the protecting groups.
9 more elements
Dependencies are inferred from the claim text.