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US 2024/0425519 A1Published application
Novel spirocyclic compounds as klhdc2 ligands
AssigneesUniversity of Washington, Accutar Biotechnology Inc.
InventorsNing ZHENG, Domnita Valeria RUSNAC, Jie FAN, Yimin QIAN, Ke LIU
Life of this patent
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Abstract
Spirocyclic compounds that are KLHDC2 ligands and methods for inhibiting the enzymatic activity of KLHDC2 using the ligands.
Claims11
A compound having formula (I):
- or a pharmaceutically acceptable salt or ester thereof,
- wherein
- X is CH2 or O;
- Y is NCH3 or CH2;
- and
- R is alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, heterocyclic alkylcarbonyl, heteroarylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl, aryl, or heteroaryl.
3 more elements
A compound having formula (II):
- or a pharmaceutically acceptable salt or ester thereof,
- wherein R1 is alkyl, aryl, cycloalkyl, alkoxy, aryloxy, heterocyclic alkyl, heteroaryl, alkylamino, or arylamino.
A compound having formula (III):
- or a pharmaceutically acceptable salt or ester thereof,
- wherein R2 is alkyl, heteroatom substituted alkyl, cycloalkyl, bicyclic alkyl, aryl, heteroaryl, bicyclic aryl, or heterobicyclic aryl.
A compound having formula (IV):
- or a pharmaceutically acceptable salt or ester thereof,
- wherein R3 is alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, heterocyclic alkylcarbonyl, heteroarylcarbonyl, or alkylaminocarbonyl, arylaminocarbonyl.
Dependencies are inferred from the claim text.