Compounds useful in prevention and/or treatment of senescent cell-related pathologies and diseases

A compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof:

• wherein R is chosen from
• phenyl, a 6-membered heteroaryl group, cyclohexyl, a 5-membered heteroaryl group;
• a bicyclo [3.1.0] hexanyl group;
• a C2-C5 alkynyl group;
• and
• a cubanyl group;
• wherein R1 and R2, independently, are chosen from
• H;
• C1-C6 alkyl (optionally substituted with one or more halogens);
• C1-C6 alkyl-S(O)n—;
• —CO2H (or C1-C6 alkyl esters thereof or C1-C6 alkyl amides thereof);
• halogen;
• C1-C6 alkoxy;
• CN;
• NO2;
• and
• NR7R8;
• wherein R7 and R8, independently, each represent H, C1-C6 alkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl, heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl, or C1-C6 alkylsulphonyl, or R7, R8 and the nitrogen to which they are attached form a 5 or 6 membered heterocyclic ring (such as morpholine or piperidine);
• and
• n represents 0-2;
• excluding a compound of formula (Ia):

A cosmetic use of a compound of formula (I) or cosmetically acceptable salts or hydrates thereof:

• wherein R is chosen from
• phenyl, a 6-membered heteroaryl group, cyclohexyl, a 5-membered heteroaryl group;
• a bicyclo [3.1.0] hexanyl group;
• a C2-C5 alkynyl group;
• and
• a cubanyl group;
• wherein R1 and R2, independently, are chosen from
• H;
• C1-C6 alkyl (optionally substituted with one or more halogens);
• C1-C6 alkyl-S(O)n—;
• —CO2H (or C1-C6 alkyl esters thereof or C1-C6 alkyl amides thereof);
• halogen;
• C1-C6 alkoxy;
• CN;
• NO2;
• and
• NR7R8;
• wherein R7 and R8, independently, each represent H, C1-C6 alkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl, heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl, or C1-C6 alkylsulphonyl, or R7, R8 and the nitrogen to which they are attached form a 5 or 6 membered heterocyclic ring (such as morpholine or piperidine);
• and
• n represents 0-2;
• to prevent, reduce, and/or treat signs of ageing of skin.