Compositions and methods for use in immunotherapy
AssigneesInstitut Curie, Inserm (Institut National De La Sante Et De La Recherche Medicale), Stimunity
InventorsNICOLAS MANEL, BAKHOS JNEID
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Abstract
The present invention relates to a pharmaceutical combination comprising i) a vector comprising a stimulator of interferon genes (STING) activator and ii) an anti-regulatory T cells (Tregs) agent, and to uses thereof, in particular for the treatment of cancer or of a STING-mediated disease or disorder.
Claims19
1-15. (canceled)
A pharmaceutical combination comprising i) a vector comprising a stimulator of interferon genes (STING) activator and ii) an anti-regulatory T cells (Tregs) agent selected from imatinib or a derivative or salt thereof;
- dasatinib or a derivative or salt thereof;
- an anti-CTLA-4 antibody having an IgG2 constant region or a mutated IgG1 constant region;
- an anti-LAG3 antibody;
- an anti-TIM-3 antibody;
- an anti-ICOS antibody;
- an anti-CD25 antibody;
- an anti-CCR4 antibody;
- an anti-CCR8 antibody;
- an anti-TNFR2 antibody;
- and any combination thereof.
A method for treating cancer in a subject comprising administering a pharmaceutical combination comprising i) a vector comprising a stimulator of interferon genes (STING) activator and ii) an anti-regulatory T cells (Tregs) agent selected from imatinib or a derivative or salt thereof;
- dasatinib or a derivative or salt thereof;
- an anti-CTLA-4 antibody having an IgG2 constant region or a mutated IgG1 constant region;
- an anti-LAG3 antibody;
- an anti-TIM-3 antibody;
- an anti-ICOS antibody;
- an anti-CD25 antibody;
- an anti-CCR4 antibody;
- an anti-CCR8 antibody;
- an anti-TNFR2 antibody;
- and any combination thereof.
A kit comprising at least two parts, wherein the first part comprises a vector comprising a stimulator of interferon genes (STING) activator and the second part comprises an anti-regulatory T cells (Tregs) agent, the first and second parts of the kit being in distinct compartments or containers.
Dependencies are inferred from the claim text.