Systems and methods for tuning absorption pathways in bioabsorbable materials
AssigneeCilag GmbH International
InventorsBRODY FROST, Madelaine Franzoni, Michael J. Vendely, Peyton Hopson
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Abstract
The disclosed technology includes a bioabsorbable material configured to be delivered to tissue. The material includes a porous body comprising at least one polymer comprising a first zone comprising a first crosslink density and a second zone comprising a second crosslink density different than the first zone. The first and second zones form a gradient of compression strength along a portion of the porous body.
Claims21
1-15. (canceled)
A bioabsorbable material configured to be delivered to tissue, the material comprising:
- a first polymerizable compound comprising a reaction product of a polyol and an isocyanate and configured to degrade according to a first degradation profile, and a second polymerizable compound configured to degrade according to a second degradation profile different than the first degradation profile;
- wherein the material undergoes a phase transition in response to exposure to a fluid comprising at least one of a predetermined temperature, an enzyme-catalyst, and a predetermined pH.
A bioabsorbable material configured to be delivered to tissue, the material comprising:
- a copolymer backbone comprising:
- a first polymerizable compound comprising a reaction product of a polyol and an isocyanate and configured to degrade according to a first degradation profile, and a second polymerizable compound configured to degrade according to a second degradation profile different than the first degradation profile;
- wherein the material undergoes a phase transition in response to exposure to the fluid comprising a predetermined temperature.
A bioabsorbable material configured to be delivered to tissue, the material comprising:
- a first polymerizable compound comprising a reaction product of a polyol and an isocyanate and configured to degrade according to a first degradation profile, and a second polymerizable compound coating the first polymerizable such that the coating prevents the first polymerizable compound from exposure to a fluid ingress for a predetermined period of time;
- wherein the material undergoes a phase transition in response to exposure to a fluid comprising a predetermined pH.
Dependencies are inferred from the claim text.