Cellular populations and uses thereof
AssigneeThe Council of the Queensland Institute of Medical Research
InventorsGeoffrey R. Hill, Ping Zhang
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Abstract
Disclosed are methods of identifying immunosuppressive TR1 regulatory T cells, including methods of diagnosing the presence of immune tolerance, methods of producing immunosuppressive regulatory T cells, and methods of eliciting immune tolerance in a subject. These methods include screeing T cells to detect Eomes +IL-10+ T cells or expressing recombinant Eomes in T cell populations to generate immunosuppressive regulatory T cells.
Claims18
A population of immunosuppressive regulatory T cells comprising Eomes+IL-10+ CD4+ T cells that comprise a construct comprising an Eomes coding sequence in operable connection with a regulatory sequence that is operable in the T cells.
Dependencies are inferred from the claim text.