US 2024/0415967 A1 · DEGRADABLE NEAR-INFRARED PHOTOSENSITIZERS, PREPARATION METHODS, APPLICATIONS THEREOF

Abstract

The present disclosure provides a degradable near-infrared photosensitizer, a preparation method, and an application thereof, and relates to the technical field of photosensitizer. The degradable near-infrared photosensitizer may be any one of a porphyrin compound, and a pharmaceutically acceptable salt, a solvate, a non-covalent bonded composite, a complex, and a prodrug of the porphyrin compound, and a structure of the porphyrin compound may be as shown in formula 1: The present disclosure further provides a preparation method for the degradable near-infrared photosensitizer and an application of the degradable near-infrared photosensitizer. The degradable near-infrared photosensitizer provided by the present disclosure may be degraded while generating reactive oxygen species during irradiation, and when the irradiation is ended, the photosensitizer may be completely converted into a low-toxicity substance that does not have the photoactivity such that effectively solves a problem of a residue of the photosensitizer in the prior art.

Claims10

Dependent claims

A degradable near-infrared photosensitizer, wherein the degradable near-infrared photosensitizer is any one of a porphyrin compound, and a pharmaceutically acceptable salt, a solvate, a non-covalent bonded composite, a complex, and a prodrug of the porphyrin compound, and a structure of the porphyrin compound is as shown in formula 1:

wherein
are independently selected from any one of
Ar1 and Ar2 are substituted or unsubstituted phenyl;
and
R1, R2, R3, R4, R5, R6, R7, and R8 are independently selected from any one of hydrogen, halogen, nitro, hydroxyl, amino, hydroxy, carboxy, carboxylic, sulfonic, phosphoric acid, cyano, amido, C1-C8 alkyl substituted amino, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C1-C8 alkoxy, substituted thio, C1-C8 alkyl phosphoryl, C1-C8 alkyl carboxy, C1-C8 alkyl sulfonyl, C3-C6 alkylene, C2-C6 alkenyl, C2-C6 alkinyl, C-C6 alkynyl, C2-C6 alkenyloxy, and C2-C6 alkynyloxy, and M is a metal ion selected from any one of Mg, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Ga, Al, Pd, and Pt.

2 more elements

Dependencies are inferred from the claim text.

Degradable near-infrared photosensitizers, preparation methods, applications thereof

Life of this patent

Degradable near-infrared photosensitizers, preparation methods, applications thereof

Life of this patent

Abstract

Claims10