Genetically engineered strains with reduced byproduct formation
AssigneeDsm IP Assets B.V.
InventorsPeter BECKER, Manos PAPADAKIS
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Abstract
The present disclosure relates to the production of oligosaccharides, especially Human milk Oligosaccharides (HMOs) using a genetically engineered cell which has decreased or total loss of function of phosphoglycerol transferase I and II and/or phosphoethanolamine transferase and/or glucans biosynthesis protein C to reduce oligosaccharide by-products and/or increase oligosaccharide production.
Claims21
A genetically engineered gram-negative bacterial cell which has decreased or total loss of function of phosphoglycerol transferase I and II or phosphoethanolamine transferase, wherein the cell comprises at least one recombinant nucleic acid sequence encoding at least one glycosyltransferase.
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Dependencies are inferred from the claim text.