Naturally available fruit-derived compounds tested to dock with presenilin-1 and amyloid precursor protein
OwnerSubhajit Dasguptainventor
Life of this patent
Estimating the term…
Abstract
The computer guided digital platform screened out test compounds in a cell free system using Molecular Docking and Molecular Dynamics. The experimental outcomes demonstrate complex structure formation between the test compounds Rhamnetin, Rosyrane, N-retinylidene-N-retinylethanolamine, Hesperidin, Trihydroxybutyrate, Trihydroxyflavone, Arylaminoethylamide with human Presenilin- and Amyloid Precursor Protein (APP). The compounds also demonstrate the ability to bind with amyloid beta (1-42) peptide. Trihydroxyflavone and its family, and arylaminoethylamide can modulate neurotransmitter release as the test compounds bind with synaptic vesicular protein VAT-1.
Claims3
The test compound Rhamnetin (PDB:
- Rha0) in its current chemical structure or functional group modified form retains the ability to bind protease enzyme Gamma Secretase (SEQ ID1;
- SEQ ID4) and Amyloid Precursor Protein (APP) (SEQ ID2;
- SEQ ID3).
The test compound Rosyrane (PDB:
- Ros0) in its current chemical structure or functional group modified form retains the ability to bind protease enzyme Gamma Secretase (Seq ID1;
- SEQ ID4) and Amyloid Precursor Protein (APP) (SEQ ID2;
- SEQ ID3).
The test compound N-retinylidene-N-retinylethanolamine (PDB:
- Ret0) in its current chemical structure or functional group modified form retains the ability to bind protease enzyme Gamma Secretase (Seq ID1;
- SEQ ID4) and Amyloid Precursor Protein (APP) (SEQ ID2;
- SEQ ID3).
Dependencies are inferred from the claim text.