Back to results
US 2024/0409515 A1Published application
Agents for differentiating stem cells and treating cancer
AssigneeMinerva Biotechnologies Corporation
InventorsCynthia Bamdad, Scott MOE
Life of this patent
Estimating the term…
Abstract
The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.
Claims21
A compound or pharmaceutically acceptable salt of:
- wherein,
- X is O, NH, S, or CH2;
- Y is O, N—R1, N—CH2—R1, CH—R1, or CH—CH2—R1;
- R0 is H, or C1-C5 alkyl;
- R1 is H, C1-C5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;
- R2 is H, or optionally substituted aryl;
- R3 is H or C1-C3 alkyl;
- m is 0 or 1;
- and
- n is 0 or 1,
- where “substituted” means substituted with one or more substituents independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, C1-C6 alkoxy, C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;
- wherein,
- R0 is H or C1-4 alkyl;
- X is O, NH or CH2;
- and
- Y is N or CH;
- wherein,
- R0 is H or C1-4 alkyl;
- and
- X is O, NH or CH2;
- or
- wherein,
- R0 is H or C1-4 alkyl;
- and
- X is O, NH or CH2.
22 more elements
Dependencies are inferred from the claim text.