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US 2024/0409509 A1Published application
Compositions for treating neurodegenerative diseases
AssigneeCognition Therapeutics, Inc.
InventorsGilbert M. RISHTON, Gary C. LOOK, Susan M. CATALANO
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Abstract
The present disclosure relates to novel compounds, pharmaceutical compositions containing the compounds and methods of using the compounds and pharmaceutical compositions for treating neurodegerative diseases, including Alzheimer's disease and cognitive decline. Methods for inhibiting synapse number decline or membrane trafficking abnormalities associated with exposure of a neuronal cell to Abeta species are also disclosed.
Claims7
-27. (canceled)
A compound of Formula I or pharmaceutically acceptable salt thereof:
- wherein:
- each of Ra, Rb, Rc, Rd and Re is independently selected from the group consisting of, H, hydroxyl, halo, C1-C10 alkyl, C1-C6 alkoxy, CF3, SO2CH3, and morpholino;
- R1 is selected from the group consisting of hydrogen, C1-C10 alkyl, phenyl, or —CH═C(CH3)2;
- and
- R2 is a cyclic amino group selected from the group consisting of
- (a)
- wherein R8 is hydrogen, hydroxyl, sulfonyl, optionally substituted C1-C10 alkyl, optionally substituted C6-C10 aryl;
- optionally substituted C5-C10 heteroaryl, optionally substituted C3-C10 cycloalkyl and optionally substituted C3-C10 heterocycloalkyl;
- or
- (b) selected from the group consisting of
7 more elements
Dependencies are inferred from the claim text.