Compositions and Methods for Labeling of Thioethers
AssigneeEmory University
InventorsMonika Raj, Benjamin Emenike
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Abstract
This disclosure relates to compositions and methods for labeling of thioethers, e.g., S-methyl thioether such as methionine or peptides containing the same. In certain embodiments, this disclosure relates to methods of forming N-(sulfaneylidene)sulfonamide labeled compounds, comprising contacting a compound containing a thioether with a N-sulfonamide or N-(tetrazol-5-yl)-suilfanimine.
Claims20
A method of labeling a thioether compound comprising contacting a compound containing a thioether, with a metal or salt thereof and compound comprising a N-sulfonamide providing a N-(sulfaneylidene)sulfonamide labeled compound formed at the thioether group.
A method of labeling a thioether compound comprising contacting a compound containing a thioether with a compound comprising a N-(iodaneylidene)sulfonamide providing a N-(sulfaneylidene)sulfonamide labeled compound formed at the thioether group.
A method of labeling a thioether compound comprising contacting a compound containing a thioether with a compound comprising a N-(iodaneylidene)cyanamide providing N-(sulfaneylidene)cyanamide compound formed at the thioether group and contacting the N-(sulfaneylidene)cyanamide compound formed at the thioether group with labeled 2-aminoethane-1-thiol providing a N-(4,5-dihydrothiazol-2-yl)-sulfanimine labeled compound.
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Dependencies are inferred from the claim text.