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US 2024/0409504 A1Published application
Compositions and methods for the treatment of cancer
AssigneeDuke University
InventorsDennis J. Thiele, Bushu Dong, Alexander M. Jaeger, Philip F. Hughes, Timothy Haystead, Jiyong Hong
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Abstract
This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.
Claims23
A compound having the structure of Formula (III)
- wherein:
- each R3a is independently selected from hydrogen, halogen, C1-C4 alkyl, halogenated C1-C4 alkyl, nitro, cyano, and —COOH;
- each R4a is independently selected from hydrogen, halogen, C1-C4 alkyl, halogenated C1-C4 alkyl, —S(O2)(halogenated C1-C4 alkyl), nitro, cyano, and —COOH;
- and
- L2 is —C(O)—;
- provided that at least one of R3a is not hydrogen and at least one of R4a is not hydrogen.
3 more elements
Dependencies are inferred from the claim text.