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US 2024/0408563 A1Published application
Systems and methods to accelerate gel-sol transition for thermoresponsive hydrogels
OwnerMark Thompson, Mahsa Rezaiyan +2inventors
InventorsMark Thompson, Mahsa Rezaiyan, Darius Shariaty, Frances Yau
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Abstract
In some examples, systems and methods are disclosed for enhancing a gel to sol transition of a polymer that includes disposing the polymer on a host material, exposing the polymer and the host material to an exposure temperature that causes the polymer to form a gel, and cooling the polymer and the host material to a cooling temperature that causes the gel to transition to a sol.
Claims20
A method for enhancing a gel to sol transition of a polymer comprising:
- disposing the polymer on a host material;
- exposing the polymer and the host material to an exposure temperature that causes the polymer to form a gel;
- and
- cooling the polymer and the host material to a cooling temperature that causes the gel to transition to a sol.
1 more element
A method for reversibly sealing tissue damage, comprising:
- applying a temperature-responsive hydrogel to a tear or perforation in a tissue of a subject in an amount effective to seal the tear, wherein when exposed to a temperature above its critical solution temperature, the temperature-responsive hydrogel becomes adhesive, and when exposed to a temperature below its critical solution temperature, the temperature-responsive hydrogel becomes less adhesive wherein the temperature-responsive hydrogel comprises a polymer disposed on a host material.
A gel forming composition, comprising:
- an aqueous solution;
- a host material;
- and
- a polymer disposed in pores of the host material, wherein the host material and the polymer are suspended in the aqueous solution;
- wherein upon exposing the polymer and host material to an exposure temperature that causes the polymer to form a temperature-responsive hydrogel gel and cooling the polymer and the host material to a cooling temperature that causes the temperature-responsive hydrogel gel to transition to a sol.
2 more elements
Dependencies are inferred from the claim text.