Implantable material in contact with blood and uses thereof
AssigneesCentre National De La Recherche Scientifique, Universite De Strasbourg, Les Hopitaux Universitaires De Geneve, Universite De Geneve
InventorsGERO DECHER, BEAT HANS WALPOTH, PIERRE FONTANA, MARIA ALICE WITT, SARRA DE VALENCE, MICHEL TSCHOPP, OLIVIER FELIX
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Abstract
The present invention is directed to materials compatible with blood, implantable devices comprising said material, methods of preparation of such material and medical devices coated therewith and uses thereof for anti-thrombotic and/or cell-proliferating aspects.
Claims22
1-22. (canceled)
A material compatible with blood comprising:
- a support comprising biocompatible non-woven fibers;
- a heparinized multilayer polymer layer-by-layer (LbL) coating of said biocompatible non-woven fibers wherein said multilayer polymer coating comprises at least one layer pair of an anionic polymer layer and a cationic polymer layer and the multilayer polymer layer-by-layer (LbL) coating is functionalized with heparin on-to the outer layer pair of said multilayer polymer coating by end-point functionalization and wherein the anionic polymer is selected from heparin and poly(sodium 4-styrene sulfonate) (PSS) or a mixture thereof and the cationic polymer is selected from chitosan or an analogue thereof and poly(allyl amine hydrochloride) (PAH) or a mixture thereof.
A method for preparing a material compatible with blood comprising the steps of:
- providing biocompatible non-woven fibers as a support;
- optionally coating said support with a pre-coating deposit comprising an adhesion agent for a multilayered polymer LbL coating;
- coating said support, pre-coated or not, with a multi-layered polymer LbL coating;
- wherein the multilayer polymer LbL coating comprises at least one layer pair of an anionic polymer layer and a cationic polymer layer wherein the anionic polymer is selected from heparin and poly(sodium 4-styrene sulfonate) (PSS) or a mixture thereof and the cationic polymer is selected from chitosan or an analogue thereof and poly(allyl amine hydrochloride) (PAH) or a mixture thereof;
- functionalizing the outer layer pair of said multilayer polymer layer-by-layer (LbL) coating with heparin by end-point functionalization.
A method for the preparation of an implantable device comprising the following steps:
- providing an implantable device or a part thereof comprising biocompatible non-woven fibers as support;
- coating said support with a heparinized multilayer polymer layer-by-layer (LbL) coating of said biocompatible non-woven fibers wherein said multilayer polymer coating comprises at least one layer pair of an anionic polymer layer and a cationic polymer layer and the multilayer polymer layer-by-layer (LbL) coating is functionalized with heparin on-to the outer layer pair of said multilayer polymer coating by end-point functionalization and wherein the anionic polymer is selected from heparin and poly(sodium 4-styrene sulfonate) (PSS) or a mixture thereof and the cationic polymer is selected from chitosan or an analogue thereof and poly(allyl amine hydrochloride) (PAH) or a mixture thereof.
Dependencies are inferred from the claim text.