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US 2024/0408188 A1Published application
Nanoemulsion adjuvant compositions for human papillomavirus vaccines
AssigneeMerck Sharp & Dohme Corp.
InventorsPatrick L. Ahl, William J. Smith, Randal J. Soukup, Nicole Lea Sullivan, John Gaspar, Julie M. Skinner
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Abstract
The present disclosure provides, among other things, a vaccine composition that includes a squalene nanoemulsion (SNE) adjuvant and HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.
Claims26
A composition comprising virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types:
- 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 69, 70, 73, and 82 and a squalene nanoemulsion (SNE) adjuvant, wherein the SNE adjuvant comprises sorbitan trioleate (SPAN-85);
- polysorbate-20 (PS-20) or polysorbate-80 (PS-80);
- and squalene.
A kit comprising:
- (a) a human papillomavirus (HPV) vaccine;
- and
- (b) a squalene nanoemulsion (SNE) adjuvant, wherein the SNE adjuvant comprises sorbitan trioleate (SPAN-85);
- polysorbate-20 (PS-20) or polysorbate-80 (PS-80);
- and squalene.
2 more elements
Dependencies are inferred from the claim text.