Silk fibroin-containing composition and methods of use thereof
AssigneeGeorgetown University
InventorsMorarji PEESAY, Makarand PARANJAPE
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Abstract
Provided are compositions comprising silk fibroin, perfluorocarbon (PFC), and surfactant, and methods of use thereof. The compositions can further comprise a drug, an antibody, or a vaccine. Compositions of the invention are useful in the treatment of certain lung diseases and conditions, including in particular those characterized by surfactant deficiency. Compositions of the invention are particularly useful in the treatment of respiratory distress syndrome (RDS). Also provided are methods for making the compositions, and kits comprising components of the compositions.
Claims34
A composition comprising silk fibroin and a perfluorocarbon.
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A composition comprising silk fibroin and a surfactant, optionally further comprising a pharmaceutically acceptable carrier.
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A composition comprising silk fibroin, a perfluorocarbon, and a surfactant, optionally further comprising a pharmaceutically acceptable carrier.
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Dependencies are inferred from the claim text.