Wee1 inhibitors and methods for treating cancer

A method of treating a cancer, comprising:

• obtaining or having obtained a biological sample from a subject;
• performing or having performed at least one assay on the biological sample to determine if the subject has altered function of CCNE1;
• and
• administering an effective amount of a compound having the structure
• or a pharmaceutically acceptable salt thereof, to the subject based upon results of the assay.

A method of treating a cancer, comprising:

• identifying a subject having (a) the cancer and (b) overexpression or altered function of CCNE1;
• and
• administering an effective amount of a compound having the structure
• or a pharmaceutically acceptable salt thereof, to the subject.

A method of treating cancer in a subject, comprising:

• determining whether the subject is sensitized to treatment with a compound having the structure
• or a pharmaceutically acceptable salt thereof, said determining comprising:
• obtaining or having obtained a biological sample from the subject;
• and
• performing or having performed at least one assay on the biological sample to determine if the subject has altered function of CCNE1;
• and
• selecting a treatment protocol for the subject on the basis of the determination of whether the subject is sensitized to treatment with the compound having the structure
• or pharmaceutically acceptable salt thereof.