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AssigneeMayo Foundation for Medical Education and Research
InventorsBarham K. Abu Dayyeh, Jason A. Tri, Samuel J. Asirvatham, Suraj Kapa, Ryan M. Kern, John J. Mullon
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Systems and methods can be used endoscopically to treat tumors in mediastinal, abdominal, and peri-rectal spaces. For example, this document describes systems and methods for endoscopic delivery of non-thermal pulsed electrical field or electroporation to such tumors. In addition, the systems and methods prime the immune system by re-introducing obtained and processed tissue or aspirates back to the local tumor environment after ex-vivo denaturing and emulsification of the tumor tissue or other immune enhancing substances such a monoclonal or multifunctional antibodies. The re-introduction of the processed tumor cells or immune enhancing substances will create an antigenic primed environment to the enhanced immune response generated by the pulsed electrical field. This will harness the power of the immune system as an ablative modality to the local tumor while systemically targeting metastatic disease.
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An endoscopic or endobronchial tumor treatment system comprising:
An endoscopic or endobronchial tumor treatment system comprising:
An endoscopic or endobronchial tumor treatment system comprising:
Dependencies are inferred from the claim text.