Systems and methods for signal deconvolution for non-contact sample ejection
AssigneeDH Technologies Development Pte. Ltd.
InventorsGordana IVOSEV, Chang LIU
Life of this patent
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Abstract
A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality of sample ejections from the sample well plate. The plurality of sample ejections is analyzed with a mass analyzer. The sample trace of intensity versus time values is produced for the plurality of sample ejections based on the analysis. A known peak shape is obtained. A convolved peak intensity is determined for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.
Claims21
A method for determining a convolved peak intensity in a sample trace, the method comprising:
- ejecting a plurality of sample ejections from a sample well plate;
- generating an ejection time log comprising an ejection time of each of the plurality of sample ejections from the sample well plate;
- analyzing the plurality of sample ejections with a mass analyzer;
- producing the sample trace of intensity versus time values for the plurality of sample ejections based on the analysis;
- obtaining a known peak shape;
- and
- determining a convolved peak intensity for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.
A mass analyzer comprising:
- a non-contact sample ejector;
- a sample receiver adjacent the non-contact sample ejector;
- a mass analysis device fluidically coupled to the sample receiver;
- a processor operatively coupled to the non-contact sample ejector, the sample receiver, and the mass analysis device;
- and
- memory coupled to the processor, the memory storing instructions that, when executed by the processor, perform a set of operations comprising:
- ejecting, with the non-contact sample ejector, a plurality of sample ejections from a sample well plate into the sample receiver;
- generating an ejection time log comprising an ejection time of each of the plurality of sample ejections from the sample well plate;
- analyzing the plurality of sample ejections with the mass analysis device;
- producing a sample trace of intensity versus time values for the plurality of sample ejections based on the analysis;
- obtaining a known peak shape;
- and
- determining a convolved peak intensity for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.
(canceled)
Dependencies are inferred from the claim text.