Method for determining a measure of relative gene expression

Abstract

A computer-implemented method for determining a measure of relative gene expression is disclosed. The method comprises: receiving a plurality of gene expression datasets, wherein each gene expression dataset comprises gene expression levels for a respective sample, and wherein the plurality of gene expression datasets are all measured using a first transcriptomic platform; computing a distribution of gene expression levels across the plurality of gene expression datasets; fitting a number of Gaussian components to the distribution of gene expression levels using a Gaussian mixture model; defining, based on the fitted Gaussian components, a set of relative gene expression thresholds for the plurality of gene expression datasets; and determining a measure of relative gene expression for each of a plurality of genes across the plurality of gene expression datasets based on the set of relative gene expression thresholds.

Dependencies are inferred from the claim text.