Systems and methods for secure genomic analysis using a specialized edge computing device

A method (600) for determining the drug resistance of a sample having tuberculosis (TB), comprising:

• receiving, by a genomic analysis unit (12/22), a sequenced data of the TB sample;
• determining, by the genomic analysis unit (12/22), the type sequencing that was performed on the TB sample;
• comparing, by the genomic analysis unit (12/22), the sequenced data with a catalogue of mutations in a TB genome, that are associated with drug resistance, to determine if there is an adequate depth of sequencing across every mutation in the sequenced data;
• and
• analyzing, by the genomic analysis unit (12/22), the drug resistance of the portion of the sequenced data that corresponds to TB (TB data), wherein the analysis is a determination of the drug resistance of the TB in the sample.

A system (100) for performing genomic analysis, comprising:

• a memory storing a plurality of instructions;
• and
• at least one processor (12/22) coupled to the memory, wherein the at least one processor (12/22) is configured to execute the plurality of instructions to perform the following:
• receiving a sequenced data of a sample, and an input based on the type of the genomic analysis to be performed on the sequenced data;
• determining the type of the sample and the type of sequencing that was performed on the sample;
• performing quality control, assembly or mapping of the sequenced data, upon which data, that is relevant to the genomic analysis type, is obtained and binned;
• comparing the relevant data with a reference genome to identify one or more variants, upon which a plurality of aberrations are obtained;
• generating a variant call format file based on the plurality of aberrations;
• and
• annotating those aberrations, among the plurality of aberrations, that are relevant to the genomic analysis type.

A system (100) for determining drug resistance of a sample including tuberculosis (TB), comprising:

• a memory storing a plurality of instructions;
• and
• at least one processor (12/22) coupled to the memory, wherein the at least one processor (12/22) is configured to execute the plurality of instructions to perform the following:
• receiving, by a genomic analysis unit (12/22), a sequenced data of the TB sample;
• determining, by the genomic analysis unit (12/22), the type sequencing that was performed on the TB sample;
• comparing, by the genomic analysis unit (12/22), the sequenced data with a catalogue of mutations in a TB genome, that are associated with drug resistance, to determine if there is an adequate depth of sequencing across every mutation in the sequenced data;
• and
• analyzing, by the genomic analysis unit (12/22), the drug resistance of the portion of the sequenced data that corresponds to TB (TB data), wherein the analysis is a determination of the drug resistance of the TB in the sample.